Study suggests timing may be key in fish-asthma link
















NEW YORK (Reuters Health) – Among thousands of Dutch children included in a new study, those who first ate fish between the ages of six months and one year had a lower risk of developing asthma-like symptoms later on than babies introduced to fish before six months of age or after their first birthdays.


According to lead author Jessica Kiefte-de Jong, of the Erasmus Medical Center in Rotterdam, and her colleagues, one theory supported by the findings is that that early exposure to certain fatty acids in fish protects against the development of asthma.













The new results, based on more than 7,000 kids in The Netherlands, cannot prove that eating fish during a particular period in infancy prevented wheezing later on, but they add to other research that suggests a connection.


“The bottom line was that there is mixed evidence of whether the introduction of a seafood diet reduced the risk of asthma,” said Dr. T. Bernard Kinane, chief of the pediatric pulmonary unit for MassGeneral Hospital for Children in Boston, who was not involved in the new study.


Concern over seafood allergies prompts some parents and doctors to delay introducing fish into babies’ diets. However, some research has found that a mother’s fish consumption during pregnancy, or the baby’s consumption of it early on, may lower asthma risk.


To see whether the timing of a baby’s first encounter with fish was linked to differences in asthma rates later in childhood, Kiefte-de Jong’s team built on previous studies.


Using health and diet information from a group of 7,210 children born between 2002 and 2006 in Rotterdam, they found that 1,281 children ate fish in their first six months of life, 5,498 first ate fish in the next six months and 431 did not eat fish until after age one.


The researchers then looked at health records for when the children were about four years old, and how many parents reported that their kids were wheezing or short of breath.


Between 40 percent and 45 percent of parents of children who did not eat fish until after their first birthday said their kids wheezed, compared to 30 percent of kids who first ate fish when they were between six and 12 months old.


That, according to the researchers, works out to be about a 36 percent decreased risk of wheezing for the kids who first had fish between ages six months and one year.


Kids who first had fish before six months of age were at similar risk to those who were introduced to it after their first birthdays.


There was no significant association between the timing of fish introduction and shortness of breath.


“They found it was only protective between six and 12 months. That would make reasonable sense because that’s when the immune system is getting educated,” Kinane said.


He added that he was relieved the researchers also found no association between the amount of fish kids ate and their risk for asthma symptoms, which means that even a small amount of fish seems to be helpful.


“The reason I like that is that it reduces the risk of kids getting too much mercury,” said Kinane.


Although Kinane said introducing children to fish between six and 12 months of age may be worth doing, he noted the possibility that there could be other explanations for the finding.


For instance, families who feed their children fish earlier and more often may be different in a variety of ways from those who do not.


“I thought it was an OK study, but I think it needs to be validated again,” Kinane said.


SOURCE: http://bit.ly/X4kl8E Pediatrics, online November 12, 2012.


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Cisco sees slower growth in second quarter
















(Reuters) – Cisco Systems Inc reported first quarter results that beat estimates but expects flat earnings and slower revenue growth for the current quarter.


“We are modeling Europe to get worse before it gets better,” Chief Executive John Chambers said on Tuesday, echoing his comments from the company’s fourth-quarter earnings call in August.













However, he added that “we see signs of improvement in the U.S. in enterprise, service provider and commercial.”


Still, Chamber said, it was too early to speak of a trend “though we are continuing to see what we like.”


Cisco said it expects earnings per share, excluding items, of 47 cents to 48 cents in its fiscal second quarter, which runs until the end of January. A year earlier it reported EPS of 47 cents.


It also said it sees revenue growth in a range of 3.5 percent to 5.5 percent, compared with 11.6 percent growth in the second quarter of 2012.


Chambers said he would give a long-term outlook at the company’s financial analyst day next month.


In its first quarter, which ran until the end of October, Cisco surprised analysts with a solid beat, due to cost cuts and the company’s broad product range.


First-quarter net income, excluding items, rose 10.6 percent to $ 2.6 billion, or 48 cents per share, compared with analysts’ average estimate of 46 cents a share as compiled by Thomson Reuters I/B/E/S.


Revenue rose 6 percent from the year-ago quarter to $ 11.9 billion, compared with a Street view of $ 11.77 billion.


Cisco’s shares rose 6.7 percent to $ 17.98 in after-hours trading.


Analysts applauded the company’s cost discipline and welcomed solid results in a tough environment.


“Given concern about enterprise spending, the company seems to be bucking the trends,” said Bill Kreher, senior technology analyst at Edward Jones.


“The bar was low but the company did exceed those expectations. The company appears to be using strong cost discipline in meeting their numbers.”


Mizuho Securities analyst Joanna Makris said “at first blush these are good numbers in a bad macro (environment).”


“It’s largely due to a product mix – a larger shift to routing – and cost cutting,” adding that “this is better than expected. We have been thinking they would squeak by on the top line.”


(Reporting by Nicola Leske; additional reporting by Liana Baker and Jennifer Saba; Editing by Phil Berlowitz)


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General investigated for emails to Petraeus friend
















PERTH, Australia (AP) — In a new twist to the Gen. David Petraeus sex scandal, the Pentagon said Tuesday that the top American commander in Afghanistan, Gen. John Allen, is under investigation for alleged “inappropriate communications” with a woman who is said to have received threatening emails from Paula Broadwell, the woman with whom Petraeus had an extramarital affair.


Defense Secretary Leon Panetta said in a written statement issued to reporters aboard his aircraft, en route from Honolulu to Perth, Australia, that the FBI referred the matter to the Pentagon on Sunday.













Panetta said that he ordered a Pentagon investigation of Allen on Monday.


A senior defense official traveling with Panetta said Allen’s communications were with Jill Kelley, who has been described as an unpaid social liaison at MacDill Air Force Base, Fla., which is headquarters to the U.S. Central Command. She is not a U.S. government employee.


Kelley is said to have received threatening emails from Broadwell, who is Petraeus’ biographer and who had an extramarital affair with Petraeus that reportedly began after he became CIA director in September 2011.


Petraeus resigned as CIA director on Friday.


Allen, a four-star Marine general, succeeded Petraeus as the top American commander in Afghanistan in July 2011.


The senior official, who discussed the matter only on condition of anonymity because it is under investigation, said Panetta believed it was prudent to launch a Pentagon investigation, although the official would not explain the nature of Allen’s problematic communications.


The official said 20,000 to 30,000 pages of emails and other documents from Allen’s communications with Kelley between 2010 and 2012 are under review. He would not say whether they involved sexual matters or whether they are thought to include unauthorized disclosures of classified information. He said he did not know whether Petraeus is mentioned in the emails.


“Gen. Allen disputes that he has engaged in any wrongdoing in this matter,” the official said. He said Allen currently is in Washington.


Panetta said that while the matter is being investigated by the Defense Department Inspector General, Allen will remain in his post as commander of the International Security Assistance Force, based in Kabul. He praised Allen as having been instrumental in making progress in the war.


The FBI’s decision to refer the Allen matter to the Pentagon rather than keep it itself, combined with Panetta’s decision to allow Allen to continue as Afghanistan commander without a suspension, suggested strongly that officials viewed whatever happened as a possible infraction of military rules rather than a violation of federal criminal law.


Allen was Deputy Commander of Central Command, based in Tampa, prior to taking over in Afghanistan. He also is a veteran of the Iraq war.


In the meantime, Panetta said, Allen’s nomination to be the next commander of U.S. European Command and the commander of NATO forces in Europe has been put on hold “until the relevant facts are determined.” He had been expected to take that new post in early 2013, if confirmed by the Senate, as had been widely expected.


Panetta said President Barack Obama was consulted and agreed that Allen’s nomination should be put on hold. Allen was to testify at his confirmation hearing before the Senate Armed Services Committee on Thursday. Panetta said he asked committee leaders to delay that hearing.


NATO officials had no comment about the delay in Allen’s appointment.


“We have seen Secretary Panetta‘s statement,” NATO spokeswoman Carmen Romero said in Brussels. “It is a U.S. investigation.”


Panetta also said he wants the Senate Armed Services Committee to act promptly on Obama’s nomination of Gen. Joseph Dunford to succeed Allen as commander in Afghanistan. That nomination was made several weeks ago. Dunford’s hearing is also scheduled for Thursday.


___


Associated Press writer Slobodan Lekic in Kabul, Afghanistan, contributed to this report.


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Belize wants to quiz anti-computer virus guru McAfee in murder probe
















BELIZE CITY (Reuters) – Police in Belize want to question U.S. anti-computer virus software pioneer John McAfee in connection with the murder of a neighbor he had been quarrelling with, but they say he remains a person of interest at this time and is not a suspect.


McAfee, who invented the anti-virus software that bears his name, has homes and businesses in Belize, and is believed to have settled in the country sometime around 2010.













“He is a person of interest at this time,” said Marco Vidal, head of Belize’s police Gang Suppression Unit. “It goes a bit beyond that, not just being a neighbor.”


Police officers were looking for the software engineer, said Miguel Segura, the assistant commissioner of police.


Asked if McAfee was a suspect, he said: “At this point, no. Our job … is to get all the evidence beyond reasonable doubt that Mr A is the one that killed Mr B.”


“He (McAfee) … can assist the investigation, so there is no arrest warrant for the fellow,” added Segura, who heads the Criminal Investigation Branch.


McAfee’s neighbor, Gregory Viant Faull, a 52-year-old American, was found on Sunday lying dead in a pool of blood after apparently being shot in the head.


McAfee has been embroiled in controversy in Belize before.


His premises were raided in May after he was accused of holding firearms, though most were found to be licensed. The final outcome of the case is pending.


McAfee also owns a security company in Belize as well as several properties and an ecological enterprise.


Reuters was unable to contact McAfee on Monday.


Segura said McAfee had been at odds with Faull for some time. He accused his neighbor of poisoning his dogs earlier this year and filed an official complaint.


“There was some conflict there between (them) … prior to the death of the gentleman,” Segura said. “But those dogs didn’t have a post mortem to see if the toxicology would confirm what type of poison, if any.”


McAfee previously accused the police Gang Suppression Unit of killing his dogs during the May raid.


McAfee was one of Silicon Valley’s first entrepreneurs to amass a fortune by building a business off the Internet.


The former Lockheed systems consultant started McAfee Associates in 1989, initially distributing its anti-virus software as “shareware” on Internet bulletin boards.


He took the company public in 1992 and left two years later following accusations that he had hyped the arrival of a virus known as Michelango, which turned out to be a dud, to scare computer users into buying his company’s products.


(Reporting by Simon Gardner and Gabriel Stargardter in Mexico City and Jim Finkle; Editing by Kieran Murray and Todd Eastham)


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U2′s Bono to urge U.S. politicians not to cut aid programs
















WASHINGTON (Reuters) – Irish rocker and anti-poverty campaigner Bono will appeal to Democrats and Republicans during a visit to Washington this week to spare U.S. development assistance programs from cuts as Congress tries to avert the looming “fiscal cliff” of tax hikes and spending reductions early next year.


The U2 lead singer’s visit comes as the Obama administration and congressional leaders try to forge a deal in coming weeks to avoid the economy hitting the “fiscal cliff” – tax increases and spending cuts worth $ 600 billion starting in January if Congress does not act.













Analysts say the absence of a deal could shock the United States, the world’s biggest economy, back into recession.


Kathy McKiernan, spokeswoman for the ONE Campaign, said Bono will hold talks with congressional lawmakers and senior Obama administration officials during the November 12-14 visit.


During meetings he will stress the effectiveness of U.S. foreign assistance programs and the need to preserve them to avoid putting at risk progress made in fighting HIV/AIDS, tuberculosis and malaria, she said.


Bono, a long-time advocate for the poor, will argue that U.S. government-funded schemes that support life-saving treatments for HIV/AIDS sufferers, nutrition programs for malnourished children, and emergency food aid make up just 1 percent of the U.S. government budget but are helping to save tens of millions of lives in impoverished nations.


The One Campaign would not elaborate which lawmakers and senior Obama administration officials Bono will meet.


On Monday, Bono will discuss the power of social movements with students at Georgetown University. He will also meet new World Bank President Jim Yong Kim for a web cast discussion on Wednesday on the challenges of eradicating poverty.


(Editing by W Simon)


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Canada seen needing to spell out rules for natural gas projects
















CALGARY, Alberta (Reuters) – The fate of a handful of liquefied natural gas projects planned for Canada’s Pacific coast may depend on the Canadian government‘s willingness to spell out rules for foreign investment in the country’s energy sector, according to a study released on Thursday.


Apache Corp, Royal Dutch Shell Plc, Petronas, BG Group Plc and others are in the planning stages for LNG projects that would take gas from the rich shale fields of northeastern British Columbia and ship it to Asian buyers.













But the federal government’s decision last month to stall the C$ 5.2 billion ($ 5.2 billion) bid by Malaysia’s state-owned Petronas C$ 5.2 billion for Canada‘s Progress Energy Resources Corp could lessen the appetite of Asian buyers for Canadian LNG, energy consultants Wood Mackenzie said.


“Some potential off-takers of Canadian LNG like the idea … because it’s perceived as having low political risk, and another reason is because they see the potential for investment opportunities,” said Noel Tomnay, head of global gas at the consultancy.


“If there are going to be restrictions on how they access those opportunities, if acquisitions are closed to them, then clearly that would restrict the attractiveness of those opportunities. If would-be Asian investors thought that corporate acquisitions were an avenue that was not open to them then Canadian LNG would become less attractive.”


The Canadian government is looking to come up with rules governing corporate acquisitions by state-owned companies and has pushed off a decision on the Petronas bid as it considers whether to approve the $ 15.1 billion offer for Nexen Inc from China’s CNOOC Ltd.


Exporting LNG to Asia is seen as a way to boost returns for natural-gas producers tapping the Montney, Horn River and Liard Basin shale regions of northeastern British Columbia.


Though Wood Mackenzie estimates the fields contain as much as 280 trillion cubic feet of gas, they are far from Canada’s traditional U.S. export market, while growing supplies from American shale regions have cut into Canadian shipments.


Because the region lacks infrastructure, developing the resource will be expensive, requiring new pipelines and multibillion-dollar liquefaction.


Still Wood Mackenzie estimates that the cost of delivery into Asian markets for Canadian LNG would be in the range of $ 10 million to $ 12 per million British thermal units, similar to competing projects in the United States and East Africa.


($ 1 = $ 1.00 Canadian)


(Reporting by Scott Haggett; Editing by Leslie Adler)


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U2′s Bono to urge U.S. politicians not to cut aid programs
















WASHINGTON (Reuters) – Irish rocker and anti-poverty campaigner Bono will appeal to Democrats and Republicans during a visit to Washington this week to spare U.S. development assistance programs from cuts as Congress tries to avert the looming “fiscal cliff” of tax hikes and spending reductions early next year.


The U2 lead singer’s visit comes as the Obama administration and congressional leaders try to forge a deal in coming weeks to avoid the economy hitting the “fiscal cliff” – tax increases and spending cuts worth $ 600 billion starting in January if Congress does not act.













Analysts say the absence of a deal could shock the United States, the world’s biggest economy, back into recession.


Kathy McKiernan, spokeswoman for the ONE Campaign, said Bono will hold talks with congressional lawmakers and senior Obama administration officials during the November 12-14 visit.


During meetings he will stress the effectiveness of U.S. foreign assistance programs and the need to preserve them to avoid putting at risk progress made in fighting HIV/AIDS, tuberculosis and malaria, she said.


Bono, a long-time advocate for the poor, will argue that U.S. government-funded schemes that support life-saving treatments for HIV/AIDS sufferers, nutrition programs for malnourished children, and emergency food aid make up just 1 percent of the U.S. government budget but are helping to save tens of millions of lives in impoverished nations.


The One Campaign would not elaborate which lawmakers and senior Obama administration officials Bono will meet.


On Monday, Bono will discuss the power of social movements with students at Georgetown University. He will also meet new World Bank President Jim Yong Kim for a web cast discussion on Wednesday on the challenges of eradicating poverty.


(Editing by W Simon)


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FDA finds contamination issues at Ameridose
















WASHINGTON (AP) — Federal health inspectors found numerous potential sources of contamination, including leaky ceilings and insects, at a drug-making facility that has the same founders as the specialty pharmacy linked to a deadly meningitis outbreak.


The Food and Drug Administration on Monday released the results of a monthlong inspection of Ameridose, a Westborough, Mass.-based company that makes injectable drugs. The agency’s report, posted online, lists a host of problems at the plant, ranging from manufacturing to sterility to quality control.













Inspectors said they found insects within 10 feet of a supposedly sterile area where drugs were manufactured. In another case, inspectors reported a bird flying into a room where drugs are stored.


Elsewhere, the report cites leaks and cracks in the ceiling and walls of a clean room used to manufacture sterile drugs. The same room contained “thick residues that were orange, brown, and green” on equipment used for sterilization.


FDA inspectors also said the company did not investigate at least 53 incidents of bacterial contamination that arose during testing of stock drug solution.


“There is no documented evidence that your firm implemented permanent corrective actions to prevent these sterility events from recurring,” investigators wrote.


Ameridose agreed to shut down for inspection in October after tainted steroids from its sister company, the New England Compounding Center, were linked to a fungal meningitis outbreak that has spread to 19 states and caused 32 deaths. Ameridose operates two facilities in Westborough and provides medication in prefilled oral syringes to hospitals nationwide. Its drugs range from painkillers to blood thinners to pregnancy drugs.


Late last month, the company agreed to recall all of its products under pressure from FDA regulators. FDA officials previously said they have not connected any Ameridose drugs to infection or illness, but they have concerns about the products’ sterility.


Inspectors visiting the company’s plant also questioned whether some of Ameridose’s drugs work properly. Inspectors said that the company received 33 complaints from patients and doctors claiming “lack of effect” with various drugs.


Regulators report that Ameridose also failed to investigate potentially serious side effects reported with drugs. One complaint involving the company’s painkiller fentanyl states the “patient was over-sedated, unresponsive.” A complaint for oxytocin, which is used to induce labor in pregnant women, states that the “patient had shortness of breath, the throat was closing, and coughing.”


Ameridose said in a statement Monday that it will work to address the issues cited by FDA. But it stressed that “Ameridose’s history shows clearly that we have not had any instance of contaminated products over the course of the past six years, which covers the manufacture and shipment of 70 million units of product.”


Ameridose and NECC were founded by brothers-in-law Barry Cadden and Greg Conigliaro. Ameridose says it is a separate entity with distinct management. Since the outbreak, Cadden, the lead pharmacist at NECC, resigned his post as director at Ameridose. He is scheduled to testify before Congress at a hearing Wednesday examining the outbreak.


Last week Ameridose laid off nearly all of its 650 employees and 140 employees at its marketing and support arm, Medical Sales Management, due to the company’s extended shutdown.


Medications/Drugs News Headlines – Yahoo! News



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How Often Do People Have Sex at the Office?
















As someone who reads people’s sex diaries professionally—for my books and website I collect thousands of them—I am here to report that former CIA Director David Petraeus is really just a talented guy who, considering his marital and work history, is a typical American male.


Petraeus has been married for 38 years. Very few human beings sleep with just one person in a 38-year period. Most people simply aren’t married that long. According to the Census, the majority of marriages end long before the 38th anniversary mark (the average divorce occurs eight years after the wedding), and of the marriages that stay intact for 38 years, approximately half involve at least one other sexual partner.













Various news outlets reported that Petraeus had sex under his desk at CIA headquarters. This makes his case a rare one. Although the workplace is the most common place to meet a new partner, few people actually have sex at the office—in the 3,500 diaries I’ve read, a grand total of 11 office affairs actually took place within the workplace walls. Workaholics logging long hours, particularly those working 12- to 18-hour days, account for seven of those 11. (Oh, and regarding the issue of on the desk vs. under the desk, I’ve discovered that people who prefer steadiness and balance—and the kinds of sexual positions given names such as “missionary,” for instance—opt for the floor. The desk is the domain of more acrobatic love-makers.)


Offices are no longer the great bastions of sex that they were in the Mad Men era, when doors were thick and carpeting thicker. The age of wide open “co-working environments,” glass walls, and security cameras has made the office a difficult place to find privacy. (Unless, of course, your office in a mid-20th-century government building is possibly camera-free and fully secure because you’re the head of U.S. intelligence—and perhaps your boss will never notice because he’s the president of the U.S. during an election year. Just saying.)


Regardless, privacy aside, there’s one thing I find to be an absolute certainty: If you communicated evidence of your lovemaking by e-mail or text message—like Petraeus apparently did—my research shows that you will likely be found out. All cheating affairs I encountered were discovered because of a digital paper trail. Remember, people: Don’t put it in writing.


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Early end-of-life talks tied to less aggressive care
















NEW YORK (Reuters Health) – Terminally-ill cancer patients are less likely to get aggressive end-of-life treatment, such as chemotherapy in the last two weeks of life, when they talk with their doctors early on about how they want to die, according to a new study.


Treatment aimed at keeping those patients alive at the end is often expensive and may not improve patients’ quality of life or comfort. Such therapies usually involve more time in the hospital rather than at home or in hospice care.













“Aggressive care at the end of life for individual patients isn’t necessarily bad, it’s just that most patients who recognize they’re dying don’t want to receive that kind of care,” said Dr. Jennifer Mack, the study’s lead author from the Dana-Farber Cancer Institute in Boston.


“We should at least consider having these discussions soon after diagnosis if we know that a patient has incurable cancer,” she told Reuters Health.


Her team’s analysis involved 1,231 people with advanced lung or colon cancer who died over a 14-month period during a larger cancer study. Researchers interviewed patients or their caregivers about whether and when the patients had discussions with their doctors about end-of-life care.


Mack and her colleagues also checked medical records for signs of those discussions and for any treatment and hospitalizations cancer patients had in their last month of life.


They found that most patients – 88 percent – had end-of-life discussions, but more than one-third of those took place less than a month before the patient died, when their health was likely already deteriorating. Close to two-thirds of the talks happened while patients were in the hospital.


Almost half of study participants received aggressive, life-prolonging care, Mack’s team reported Monday in the Journal of Clinical Oncology.


Those who’d had end-of-life discussions more than a month before dying were 50 to 60 percent less likely to get that extra treatment than patients who put off those talks or didn’t have them at all.


Patients (and their caregivers) who reported having the discussions with doctors were almost seven times more likely to end up in hospice than those who didn’t recall end-of-life talks.


“A lot of patients don’t want (aggressive treatment), but they don’t recognize that they’re dying or that this is relevant for them,” said Dr. Camilla Zimmermann, head of the palliative care program at University Health Network in Toronto.


But, she told Reuters Health, “The earlier you discuss these things, the more options you have. If you wait too long, you end up having these discussions with someone you don’t know, that you just met, in an inpatient setting,” instead of with your primary doctor.


Mack agreed.


“If we start these conversations early, then patients have some time to process this information, to think about what’s important to them (and) to talk with their families about that,” she said.


Aggressive end-of-life care is also expensive. According to data from the Dartmouth Atlas of Health Care, 32 percent of total Medicare spending goes to caring for very sick patients in their last two years of life, often because those people are in and out of the hospital. In the early 2000′s, that spending was equal to about $ 46,000 per chronically-ill patient.


Zimmermann, who wasn’t involved in the new research, believes it’s never too early for doctors, patients or caregivers to initiate discussions about end-of-life preferences – even if it can be an uncomfortable topic.


“There are many opportunities while that incurable illness is still being treated… to also focus on what happens if this doesn’t work,” she said.


“I think people are afraid that bringing up these discussions is going to make them die. Bringing up these discussions is really going protect them from an outcome they don’t want in the end.”


SOURCE: http://bit.ly/gPtMdm Journal of Clinical Oncology, online November 12, 2012.


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